SCIENTIFIC PAPERS – THE PLAQUE PROJECT

A selection of scientific articles resulting from the studies and projects of the Cardiology Network.

The PLAQUE Project – Integrated strategies for the study of cellular and genomic determinants of atheromatous plaque

THE PLAQUE PROJECT WP1 – Characterization of cellular and molecular components of carotid atherosclerotic plaques

rs41291957 CONTROLS miR-143 AND miR-145 EXPRESSION AND IMPACTS CORONARY ARTERY DISEASE RISK

Hall IF, Climent M, Viviani Anselmi C, Papa L, Tragante V, Lambroia L, et al. rs41291957 CONTROLS miR-143 AND miR-145 EXPRESSION AND IMPACTS CORONARY ARTERY DISEASE RISK. EMBO Mol Med. 2021;13(10):e14060. Epub 2021/09/23. doi: 10.15252/emmm.202114060. PMID: 34551209. → See more

THE PLAQUE PROJECT WP4 – Pathophysiological and prognostic role of calcification mediating molecules in carotid stenosis

FICOLIN-2 SERUM LEVELS PREDICT THE OCCURRENCE OF ACUTE CORONARY SYNDROME IN PATIENTS WITH SEVERE CAROTID ARTERY STENOSIS

Carbone F, Valente A, Perego C, Bertolotto M, Pane B, Spinella G, et al. Ficolin-2 serum levels predict the occurrence of acute coronary syndrome in patients with severe carotid artery stenosis. Pharmacol Res. 2021;166:105462. Epub 2021/01/30. doi: 10.1016/j.phrs.2021.105462. PMID: 33513354. →  See more

THE PLAQUE PROJECT – WP 4

ANTI-APOLIPOPROTEIN A-1 IGG INFLUENCES NEUTROPHIL EXTRACELLULAR TRAP CONTENT AT DISTINCT REGIONS OF HUMAN CAROTID PLAQUES

da Silva RF, Baptista D, Roth A, Miteva K, Burger F, Vuilleumier N, et al. Anti-Apolipoprotein A-1 IgG Influences Neutrophil Extracellular Trap Content at Distinct Regions of Human Carotid Plaques. Int J Mol Sci. 2020;21(20). Epub 2020/10/23. doi: 10.3390/ijms21207721. PMID: 33086507. → See more

THE PLAQUE PROJECT WP5 – Transcriptional biomarkers and protective gene variants against atherosclerotic coronary heart disease

WHOLE-BLOOD TRANSCRIPTOME PROFILE AT HOSPITAL ADMISSION DISCRIMINATES BETWEEN PATIENTS WITH ST-SEGMENT ELEVATION AND NON-ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION

Chiesa M, Piacentini L, Bono E, Milazzo V, Campodonico J, Marenzi G, Colombo GI. Whole-blood transcriptome profile at hospital admission discriminates between patients with st-segment elevation and non-st-segment elevation acute myocardial infarction. Sci Rep 2020;10:8731. Doi: 10.1038/s41598-020-65527-7. PMID: 32457432. → See more

THE PLAQUE PROJECT – WP5

CIRCULATING MICRORNAS AS NOVEL BIOMARKERS IN RISK ASSESSMENT AND PROGNOSIS OF CORONARY ARTERY DISEASE

Vavassori C, Cipriani E, Colombo GI. Circulating microRNAs as novel biomarkers in risk assessment and prognosis of coronary artery disease. Eur Cardiol Rev 2022, in press. doi: 10.15420/ecr.2021.47.  → See more

THE PLAQUE PROJECT WP7 – Characterization of culprit aspiration material culprit lesions in acute coronary syndromes in in vivo diagnostics of plaque substrates the thrombus

ON THE SHADES OF CORONARY CALCIUM AND PLAQUE INSTABILITY

Arbustini E, Vengrenyuk Y, Narula J. On the shades of coronary calcium and plaque instability. J Am Coll Cardiol. 2021;77(13):1612-5. Epub 2021/04/03. doi: 10.1016/j.jacc.2021.02.011. PMID: 33795034. → See more