CV Prevital

Digital strategies in primary cardiovascular prevention in the Italian population



The research project “Digital strategies in primary cardiovascular prevention in the Italian population (CV PREVITAL)” has been promoted and financed by the Italian Ministry of Health with a total amount of 10 million euros, according to Law no. 136 of 17 December 2018 and Law no. 145 of 30 December 2018. Implemented by the Cardiology Network, and in particular by the IRCCS of this network with experience in primary prevention programs, in collaboration with the National Consortium of General Practitioners (MMG) Co.S., the Italian Society for Digital Health and Telemedicine and the Romeo and Enrica Invernizzi Foundation, the project has as its overall objective the implementation of an innovative model of primary cardiovascular prevention and its validation in a very large sample of subjects in “real life” conditions.


Cardiovascular disease (CVD) is the leading cause of mortality and morbidity globally and is one of the main items of public health spending. In Italy, healthcare expenditure is growing by 2.7% per year, largely due to CVD, and it is expected that this expenditure will double by 2040, a burden that is difficult to sustain by our National Health System. In the face of the numerous information available today in the field of prevention, the application of prevention programmes at a population level is still limited. The CV PREVITAL project aims to assess the feasibility of an innovative primary cardiovascular prevention intervention to be implemented through the early identification of subjects at risk, the implementation of programmes aimed at modifying non-virtuous lifestyles and appropriate information to the subjects concerned, in association with adequate pharmacological correction where necessary. The project proposes a paradigm shift, combining conventional approaches of primary cardiovascular prevention (usual care) with digital medicine, and gives a strategic role to new information technologies able to monitor and manage in an optimal way the path of prevention, putting in synergy the different actors, such as the citizen first of all, the GPs, medical specialists, care-givers, diagnostic centers, pharmacies, etc. The specific objectives of the project are: i) to evaluate the effectiveness of a digital medicine intervention based on the use of an App and aimed at the monitoring, education and remote management of cardiovascular risk factors (conventional and non-conventional) and to detect/modify incorrect lifestyles (e.g. inappropriate diet, insufficient physical activity), in the natural context of primary prevention, i.e. general medicine; ii) developing new algorithms for the estimation of cardiovascular risk, also based on the use of artificial neural networks; iii) cost-effectiveness analysis of interventions; iv) improving communication among GPs, NHS structures, Ministry of Health and IRCCSs, through the integration of existing IT platforms.

Lead institution:

Centro Cardiologico Monzino

Project leader:

Prof. Elena Tremoli

Scientific coordinator:

Prof. Damiano Baldassarre

Participating institutions:

The project involves 14 Scientific Institutes for Research, Hospitalization and Health Care (Istituti di Ricovero e Cura a Carattere Scientifico, IRCCS) belonging to the Italian Cardiology Network (Rete Cardiologica Italiana): Centro Cardiologico Monzino – Istituto Auxologico Italiano – Istituto Clinico Humanitas – Istituto di Ricerche Farmacologiche Mario Negri – MultiMedica – Istituto Neurologico Mediterraneo Neuromed – Policlinico San Donato – Istituti Clinici Scientifici Maugeri – ISMETT, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione – Ospedale Policlinico San Martino – Fondazione Cà Granda Ospedale Maggiore Policlinico – Policlinico Universitario Fondazione Agostino Gemelli – Fondazione Policlinico San Matteo – San Raffaele Pisana. Participants also include: Consorzio Sanità (Co.S., a national consortium of MMG cooperatives operating in the National Health Service); the Italian Society for Telemedicine and eHealth (Digital S.I.T.); and the Romeo ed Enrica Invernizzi Foundation.