Heart failure

In Western countries, heart failure is a public health problem and represents an important cost not only for the health system but also for the patient himself. Heart failure consumes about 1-2% of healthcare resources, mainly due to repeated hospitalization and prolonged hospital stays. Demographic changes and the epidemiological transition of non-communicable diseases mean that heart failure, in its many forms and causes, is bound to increase, in an important way, thus becoming an ever-increasing public health problem in the near future.

Numerous researches, conducted in different countries and in different clinical and pathological contexts, have confirmed the multifactorial character of the syndrome of heart failure due to the heterogeneous component of co-patologies that determine not only its clinical expression, but, more and more often, aggravation and the need for hospitalization for acute events. The Working Group HEART FAILURE of the RETE CARDIOLOGICA concentrates a large part of the efforts in the direction of obtaining useful information to improve the prognosis of heart failure through the use of two different approaches:

  1. Clinical approach: aims to collect clinical information and outcomes in hospitalized patients hospitalized for acute decompensated heart failure. This data will provide for the first time significant clinical information on selected sub-populations of patients not adequately represented in traditional clinical trials and will allow the creation of a single tool for health management strategies
  2. Translational approach: aims at the validation of which diagnostic and prognostic marker of the progression of heart failure, usable in clinical practice. Studies are currently underway to define the role of SPB (Surfactant Protein B) both as a diagnostic marker and as a marker for disease progression.

The Working Group (WG) is also interested in the following topics:

  • Polypharmacological approach to the treatment of heart failure;
  • Kinetics of biomarkers of pulmonary edema;
  • Multiparameter approach to chronic heart failure;
  • Sleep disorders and chronic heart failure;
  • Pulmonary hypertension.

Active Projects:
  • The FAiling HearT in the Elderly (FATE) Registry (PI: Gaia Cattadori, MultiMedica)
  • Validation of Type B pulmonary surfactant protein levels as a diagnostic and prognostic marker in the progression of heart failure (PI: Piergiuseppe Agostoni, Monzino)
Coordinator:

Prof. Piergiuseppe Agostoni

Insitute:

IRCCS Centro Cardiologico Monzino

Partecipants:

POLICLINICO SAN DONATO Marco Guazzi – MULTIMEDICA Gaia Cattadori – AUXOLOGICO Alessandra Villani – FONDAZIONE CA’ GRANDA Marco Vicenzi – OSPEDALE SAN RAFFAELE  Paolo Camici – MARIO NEGRI Lidia Staszewsky – OSPEDALE PEDIATRICO BAMBINO GESU’ Rachele Adorisio – POLICLINICO SAN MATTEO Carlo Pellegrini – IRCCS ISTITUTI CLINICI SCIENTIFICI MAUGERI Maria Teresa La Rovere – HUMANITAS Cristina Panico – SAN RAFFAELE PISANA Maurizio Volterrani – ISMETT IRCCS Piero Levantino – SDN Carlo Cavaliere – NEUROMED Giuseppe Lembo – IRCCS OSPEDALE POLICLINICO SAN MARTINO Pietro Ameri – ISTITUTO GIANNINA GASLINI Maria Derchi – IRCCS POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI Domenico D’Amario – IRCCS INRCA Roberto Antonicelli